Western Australian Institute for Medical Research (WAIMR)


http://www.waimr.uwa.edu.au

Dr Shane Colley

Shane Colley

Dr Shane Colley completed a Bachelor of Science at the University of Western Australia (UWA) in 1988, majoring in Microbiology and Molecular Biology, then a Post Graduate Diploma in Biotechnology and Molecular Biology in 1989 at the same insitution. His subsequent PhD studies centred around understanding alterations in gene expression following v-raf transfection induced macrophage lineage switching in Eµ-myc B cells and was conducted within the Department of Biochemistry at UWA with Professor Peter Klinken and awarded in 1998. Having completed his PhD studies he worked as a post doctoral fellow at the University of Bristol in the UK for three and a half years investigating the effects of oestrogen on gene expression in mouse bone marrow.

In 2002, Shane returned to Perth and WAIMR working with Professor Peter Leedman, characterising SLIRP, a novel, SRA binding, nuclear receptor co-regulator. These studies were initially focused on the role of SLIRP in nuclear receptor function in breast and prostate cancer but have now expanded into the area of energy and lipid metabolism.

Qualifications

1988BSc - Microbiology and Molecular Biology, University of Western Australia, Australia
1989PGDipSc - Biotechnology and Molecular Biology, University of Western Australia, Australia
1998PhD - Department of Biochemistry, University of Western Australia, Australia
Thesis Title: "Analyses of Eµ-myc B cell and v-raf transfection derived myeloid lines"

Research Interests

  • The activities of nuclear receptors and their co-regulators.
  • The effects of the nuclear receptor co-repressor SLIRP in breast and prostate cancer.
  • The role of SLIRP in regulating energy and lipid metabolism in fat and muscle.

Scientific Involvement

  • Combined Biological Sciences Meeting - Co-Chair of the Organising Committee 2006 to 2007.

Major Grants Awarded

  • Royal Perth Hospital Medical Research Foundation Grant 2007 - "Regulation of energy metabolism and insulin resistance by SLIRP".

Top 10 Publications

  1. Colley SM, Leedman PJ. 2007. The RNA Coregulator SRA, its Binding Proteins and Nuclear Receptor Signaling Activity. Australian Biochemist 38:16-8.
  2. Lee YB, Colley S, Norman M, Biamonti G, Uney JB. 2007. SAFB re-distribution marks steps of the apoptotic process. Experimental Cell Research (in press). [NCBI PubMed Entry]
  3. Hatchell EC*, Colley SM*, Beveridge DJ, Epis MR, Stuart LM, Giles KM, Redfern AD, Miles LE, Barker A, MacDonald LM, Arthur PG, Lui JC, Golding JL, McCulloch RK, Metcalf CB, Wilce JA, Wilce MC, Lanz RB, O'Malley BW, Leedman PJ. 2006. SLIRP, a small SRA binding protein, is a nuclear receptor corepressor. Molecular Cell 22(5):657-68. [NCBI PubMed Entry] [IF 16.8]
  4. Ong DB, Colley SM, Norman MR, Kitazawa S, Tobias JH. 2004. Transcriptional regulation of a BMP-6 promoter by estrogen receptor alpha. Journal of Bone and Mineral Research 19(3):447-54. [NCBI PubMed Entry] [IF 6.2]
  5. Plant A, Samuels A, Perry MJ, Colley S, Gibson R, Tobias JH. 2002. Estrogen-induced osteogenesis in mice is associated with the appearance of Cbfa1-expressing bone marrow cells. Journal of Cellular Biochemistry 84(2):285-94. [NCBI PubMed Entry] [IF 2.8]
  6. McDougall KE, Perry MJ, Gibson RL, Bright JM, Colley SM, Hodgin JB, Smithies O, Tobias JH. 2002. Estrogen-induced osteogenesis in intact female mice lacking ERbeta. American Journal of Physiology: Endocrinology and Metabolism 283(4):E817-23. [NCBI PubMed Entry] [IF 4.1]
  7. Samuels A, Perry MJ, Gibson RL, Colley S, Tobias JH. 2001. Role of endothelial nitric oxide synthase in estrogen-induced osteogenesis. Bone 29(1):24-9. [NCBI PubMed Entry] [IF 4.0]
  8. Tilbrook PA, Colley SM, McCarthy DJ, Marais R, Klinken SP. 2001. Erythropoietin-stimulated Raf-1 tyrosine phosphorylation is associated with the tyrosine kinase Lyn in J2E erythroleukemic cells. Archives of Biochemistry and Biophysics 396(1):128-32. [NCBI PubMed Entry] [IF 2.6]
  9. Colley SM, Chappell DS, Busfield SJ, Voon DC, Klinken SP. 2000. Karyotypic abnormalities associated with haemopoietic lineage switching are not linked with mutations to p53. The International Journal of Biochemistry and Cell Biology 32(5):509-17. [NCBI PubMed Entry] [IF 2.9]
  10. Colley SM, Tilbrook PA, Klinken SP. 1997. Increased transcription of the E mu-myc transgene and mRNA stabilisation produce only a modest elevation in Myc protein. Oncogene 14(22):2735-9. [NCBI PubMed Entry] [IF 6.5]

* Hatchell and Colley are Co-First Authors of this paper