Western Australian Institute for Medical Research (WAIMR)


http://www.waimr.uwa.edu.au

Associate Professor Karin Eidne

Karin Eidne

Associate Professor Eidne spent 12 years at the Medical Research Council Reproductive Biology unit in Edinburgh, United Kingdom, and in 1999 relocated to Australia to establish the 7TM Receptor Laboratory in WAIMR (Western Australian Institute for Medical Research) where she heads the study for cellular signalling pathways and their role in disease states.

Her expertise lies in the field of endocrinology and the molecular function of G-protein coupled receptors. She has published over 100 articles and has an outstanding track record of attracting competitive research funding.

Karin has also patented novel receptor genes and licensed cell lines, some of which have been purchased by commercial companies, and has established collaborative links with many national and international academic groups as well as industry.

Karin was responsible for the development of novel bioluminescence resonance energy transfer (BRET) an advanced generation of a protein-protein interaction assay technology and this team was the first site in Australia to introduce the novel system and was the first to publish a paper describing this approach in the high impact Journal of Biological Chemistry.

Karin is also a founder of Dimerix, a drug discovery company which has been formed out of her laboratory.

Qualifications

MBA, PhD

Positions Held

2002-2007NHMRC Principal Research Fellow, University of Western Australia
2000-2002Keogh Raine Fellow, University of Western Australia
1992-1999Senior Scientist, Reader Level, Medical Research Council, Reproductive Biology Unit
1986-1986Consultant, Genetech
1986-1992Scientist Grade 1, Medical Research Council, Reproductive Biology Unit
1985-1986Senior Medical Scientist, MRC Regulatory Peptides Research Unit, Chemical Pathology
1983-1985Medical Scientist, MRC Regulatory Peptides Research Unit, Chemical Pathology
1982-1983Postdoctoral Fellow, MRC Liver Research Unit, Medicine
1978-1982Research Biochemist, Council for Scientific and Industrial Research (CSIR), Chromatin Research Unit
1976-1978Research Assistant, Council for Scientific and Industrial Research (CSIR), Chromatin Research Unit

Research Interests

  • Development of BRET detection systems
  • Novel G-protein coupled receptor interactions
  • G-protein coupled receptor pathways in reproductive function
  • Orexins and orexin receptors

Scientific Involvement

  • Biochemical Society
  • Endocrine & Reproductive Biology Society
  • Endocrine Society
  • Endocrine Society of Australia
  • Fedration of American Societies of Experimental Biology
  • International Neuroendocrine Federation
  • Pituitary Society
  • The Australian Society for Medical Research

Top 10 Publications

  1. Kroeger KM, Pfleger KD, Eidne KA. 2003. G-protein coupled receptor oligomerization in neuroendocrine pathways. Front Neuroendocrinol 24:254-78.
  2. Eidne KA, Hanyaloglu A, Kroeger KM. 2002. Applications of novel resonance energy transfer techniques to study dynamic receptor interactions in living cells. Trends Endocrin Met 13:415-21.
  3. Scaffidi AK, Petrovic N, Moodley YP, Fogel-Petrovic M, Kroeger KM, Seeber RM, Eidne KA, Thompson PJ, Knight DA. 2004. alpha(v)beta(3) Integrin interacts with the TGFbeta type II receptor to potentiate the proliferative effects of TGFbeta 1 in living human lung fibroblasts.J Biol Chem 279:37726-33.
  4. Hanyaloglu A, Seeber R, Kohout A, Lefkowitz RJ, Eidne KA. 2002. Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2. J Biol Chem 277:50422-30.
  5. Hanyaloglu AC, Vrecl M, Kroeger KM, Miles LEC, Qian H, Thomas WG, Eidne KA. 2001. Casein Kinase II sites in the intracellular C-terminal domain of the thyrotropin-releasing hormone receptor and chimericgonadotropin-releasing hormone receptors contribute to beta-arrestin-dependent internalization. J Biol Chem 276:18066-74.
  6. Kroeger K, Hanyaloglu A, Seeber R, Miles L, Eidne KA. 2001. Constitutive and agonist-dependent homo-oligomerization of the thyrotropin releasing hormone receptor.Detection in living cells using bioluminescence resonance energy transfer. J Biol Chem 276:12736-43.
  7. Willars GB, Heding A, Vrecl M, Sellar R, Blomenrohr M, Nahorski SR, Eidne KA. 1999. Lack of a C-Terminal tail in the mammalian gonadotropin-releasing hormone receptor confers resistance to agonist-dependent phosphorylation and rapid desensitization. J Biol Chem 274:30146-53.
  8. Drmota T, Novotny J, Kim G-D, Eidne KA, Milligan G, Svoboda P. 1998. Agonist induced internalization of the G protein G11alpha and thyrotropin releasing hormone receptors proceed on different time scales.J Biol Chem 273:21699-707.
  9. Heding A, Vrecl M, Bogerd J, McGregor A, Sellar R, Taylor PL, Eidne KA. 1998. Gonadatropin-releasing hormonereceptors with intracellular carboxyl-terminal tails undergo acute densensitization of total inositol phosphate production and exhibit accelerated internalization kinetics. J Biol Chem 273:11472-7.
  10. Vrecl M, Anderson L, Hanyaloglu A, McGregor A, Groarke AD, Milligan G, Taylor PL, Eidne KA. 1998. Agonist induced endocytosis and recycling of the gonadotropin-releasing hormone receptor: effect of beta-arrestin on internalization kinetics. Mol Endocrinol 12:1818-29.